MT1E

Chr 16

metallothionein 1E

Also known as: MT-1E, MT-IE, MT1, MTD

NCBI Gene: 4493 ENSG00000169715 UniProt: P04732 OMIM: 156351

Metallothionein 1E binds zinc and other heavy metals through its cysteine-rich structure and is regulated by heavy metal exposure and glucocorticoids. Mutations in MT1E have been associated with neurodevelopmental disorders, though the clinical phenotype and inheritance patterns are not well-established in the current literature. This gene shows low constraint against loss-of-function variants, suggesting tolerance to such mutations.

OMIM ResearchSummary from RefSeq, UniProt

Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.83

LOEUF

Multiple*

Mechanism· predicted