MT1B

Chr 16

metallothionein 1B

Also known as: MT-1B, MT-IB, MT1, MT1Q, MTP

NCBI Gene: 4490ENSG00000169688UniProt: P07438

The protein encoded by this gene binds heavy metals and protects against toxicity from heavy metal ions. This gene is found in a cluster of similar genes on chromosome 16. [provided by RefSeq, Jul 2016]

ResearchGenerating clinical summary…
0
Active trials
3
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.88
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.88LOEUF
pLI 0.005
Z-score -0.16
OE 1.11 (0.46–1.88)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.02Z-score
OE missense 0.99 (0.75–1.32)
34 obs / 34.3 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.11 (0.46–1.88)
0≤0.351.4
Missense OE?0.99 (0.75–1.32)
0≤0.61.4
Synonymous OE?0.72
0≤1.21.6
LoF obs/exp: 3 / 2.7Missense obs/exp: 34 / 34.3Syn Z: 0.82

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

MT1B · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients