MSH5-SAPCD1
Chr 6MSH5-SAPCD1 readthrough (NMD candidate)
Also known as: MSH5-C6orf26
This locus represents naturally occurring read-through transcription between the neighboring mutS homolog 5 (MSH5) and chromosome 6 open reading frame 26 (C6orf26) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011]
Some data sources returned errors (1)
clinvar: Error: NCBI fetch failed: 429 https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
129 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | 3 | 1 | 1 | 0 | 5 |
Likely Pathogenic | 0 | 2 | 1 | 0 | 3 |
VUS | 1 | 94 | 1 | 0 | 96 |
Likely Benign | 0 | 13 | 3 | 1 | 17 |
Benign | 0 | 4 | 0 | 3 | 7 |
Conflicting | — | 1 | |||
| Total | 4 | 114 | 6 | 4 | 129 |
LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
MSH5-SAPCD1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
OMIM — Genotype-Phenotype
No OMIM entries found.
External Resources
Links to major genomics databases and tools
Variant Interpretation
Population Databases
Gene Resources
Expert Curation
No publications found for MSH5-SAPCD1
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools