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MRXSSB

Chr XXLDXLR

DEAD-box helicase 3 X-linked

Also known as: CAP-Rf, DBX, DDX14, DDX3, HLP2, MRX102, MRXSSB

This gene encodes DDX3X, an ATP-dependent RNA helicase that regulates transcription, pre-mRNA splicing, mRNA export, and translation in both nuclear and cytoplasmic compartments. Mutations cause intellectual developmental disorder, X-linked syndromic, Snijders Blok type, which presents with developmental delay, intellectual disability, and various syndromic features. The condition follows X-linked inheritance patterns and can manifest in both males and females.

GeneReviewsOMIMResearchSummary from RefSeq, OMIM
XLD/XLR1 OMIM phenotype
📖
GeneReview available — MRXSSB
Authoritative clinical overview · Recommended first read
Open GeneReview ↗
Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/MRXSSB?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

MRXSSB · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
Open Research Assistant →
Key Publications
Landmark & review papers · by relevance
PubMed
Top 2 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found