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MRT34
Chr 12ARCARD and death domain containing adaptor protein
Also known as: MRT34, RAIDD
This protein contains a death domain motif and recruits caspase 2 to cell death signaling complexes that include TNFR1A and RIPK1, promoting apoptosis. Mutations cause autosomal recessive intellectual developmental disorder with variant lissencephaly, indicating involvement of both cognitive development and cortical brain formation. The inheritance pattern is autosomal recessive.
Some data sources returned errors (2)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/MRT34?content-type=application/json&expand=1
gnomad: Error: Gene not found
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
MRT34 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools