MRPL37
Chr 1mitochondrial ribosomal protein L37
Also known as: L2mt, L37mt, MRP-L2, MRP-L37, MRPL2, RPML2, mL37
This protein is a component of the large 39S subunit of mitochondrial ribosomes, which synthesize proteins essential for mitochondrial function. Mutations cause autosomal recessive mitochondrial disorders with variable presentations that can include developmental delay, seizures, and multi-organ dysfunction. The gene shows minimal constraint against loss-of-function variants (very low pLI score), suggesting that complete loss of function may be tolerated in the heterozygous state.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
MRPL37 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools