MROH7
Chr 1maestro heat like repeat family member 7
Also known as: C1orf175, HEATR8
MROH7 encodes a protein located in the extracellular space, though its specific function remains unclear. The gene shows very low constraint against loss-of-function variants (pLI near 0, LOEUF ~1.0), suggesting it may tolerate protein-disrupting mutations well. No established human diseases have been definitively linked to MROH7 mutations at this time.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
MROH7 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools