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MRD63
Chr 5ADtrio Rho guanine nucleotide exchange factor
Also known as: ARHGEF23, MEBAS, MRD44, MRD63, tgat
This gene encodes a GDP to GTP exchange factor that promotes reorganization of the actin cytoskeleton for cell migration and growth. Mutations cause autosomal dominant intellectual developmental disorder with macrocephaly. The disorder follows an autosomal dominant inheritance pattern.
Some data sources returned errors (2)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/MRD63?content-type=application/json&expand=1
gnomad: Error: Gene not found
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
MRD63 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools