MORF4L2

The protein is a component of the NuA4 histone acetyltransferase complex that regulates gene transcription through chromatin modification and participates in DNA double-strand break repair via homologous recombination. Mutations cause autosomal dominant neurodevelopmental disorder with variable intellectual disability, behavioral abnormalities, and dysmorphic features. This gene is highly constrained against loss-of-function variants, indicating that such mutations are likely to be pathogenic.