MORF4L2

Chr X

mortality factor 4 like 2

Also known as: MORFL2, MRGX

NCBI Gene: 9643 ENSG00000123562 UniProt: Q15014

The protein is a component of the NuA4 histone acetyltransferase complex that regulates gene transcription through chromatin modification and participates in DNA double-strand break repair via homologous recombination. Mutations cause autosomal dominant neurodevelopmental disorder with variable intellectual disability, behavioral abnormalities, and dysmorphic features. This gene is highly constrained against loss-of-function variants, indicating that such mutations are likely to be pathogenic.

ResearchSummary from RefSeq, UniProt

Involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

LOF

Mechanism· predicted

Some data sources returned errors (2)