MORC1
Chr 3MORC family CW-type zinc finger 1
Also known as: CT33, MORC, ZCW6
The protein is required for spermatogenesis and is essential for de novo DNA methylation and silencing of transposable elements in male embryonic germ cells. Mutations in MORC1 cause male infertility with no other apparent clinical phenotype. The gene shows extremely high constraint against loss-of-function variants (pLI near 1.0), suggesting that mutations may have significant biological impact despite the testis-specific expression pattern.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
The highest-scoring mechanism for this gene is dominant-negative.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
MORC1 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools