MNS16A

Chr 5

MNS16A minisatellite promoter

NCBI Gene: 110806265

This region represents a promoter located downstream of the telomerase reverse transcriptase (TERT) gene. This sequence contains a VNTR (variable number tandem repeat) minisatellite sequence that may be associated with cancer risk. [provided by RefSeq, Aug 2017]

63
ClinVar variants
56
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— MNS16A
📋
ClinVar Variants
56 Pathogenic / Likely Pathogenic· 5 VUS of 63 total submissions
Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/MNS16A?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

63 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic56
VUS5
Likely Benign2
56
Pathogenic
5
VUS
2
Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————56
Likely Pathogenic
————0
VUS
————5
Likely Benign
————2
Benign
————0
Total—63

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

MNS16A · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Effect of obesity and NAFLD on leukocyte telomere length and hTERT gene MNS16A VNTR variant.
Kandemir I et al.·Sci Rep
2024
MNS16A minisatellite genotypes in relation to risk of glioma and meningioma and to glioblastoma outcome.
Andersson U et al.·Int J Cancer
2009
Survival prediction in patients with glioblastoma multiforme by human telomerase genetic variation.
Wang L et al.·J Clin Oncol
2006Cohort
Clinical relevance of telomerase polymorphism for breast cancer: A systematic review.
de Souza Rodrigues K et al.·J BUON
2017Review
Association of hTERT MNS16A polymorphism with clinical outcomes of North Indian lung cancer patients undergoing platinum-based doublet chemotherapy.
Kaur I et al.·Clin Transl Oncol
2025Cohort
Role of the functional MNS16A VNTR-243 variant of the human telomerase reverse transcriptase gene in progression and response to therapy of patients with non-Hodgkin's B-cell lymphomas.
Wysoczanska B et al.·Int J Immunogenet
2015Cohort
MNS16A tandem repeats minisatellite of human telomerase gene: a risk factor for colorectal cancer.
Hofer P et al.·Carcinogenesis
2011
MNS16A tandem repeat minisatellite of human telomerase gene and prostate cancer susceptibility.
Hofer P et al.·Mutagenesis
2013
Association between hTERT polymorphisms and the risk of breast cancer in a sample of Southeast Iranian population.
Hashemi M et al.·BMC Res Notes
2014
Relationship between Telomere Length, TERT Genetic Variability and TERT, TP53, SP1, MYC Gene Co-Expression in the Clinicopathological Profile of Breast Cancer.
Dratwa M et al.·Int J Mol Sci
2022
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools