MIRLET7F1

Chr 9

microRNA let-7f-1

Also known as: LET7F1, MIRNLET7F1, let-7f-1

NCBI Gene: 406888ENSG00000199072OMIM: 612146

This microRNA regulates gene expression by binding to target mRNAs and inhibiting their translation or promoting their degradation. No disease associations have been established for mutations in MIRLET7F1 based on the available information.

OMIMResearchSummary from RefSeq
Clinical Summary— MIRLET7F1
📋
ClinVar Variants
33 unique Pathogenic / Likely Pathogenic· 3 VUS of 36 total submissions
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Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

36 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic29
Likely Pathogenic4
VUS3
29
Pathogenic
4
Likely Pathogenic
3
VUS

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————29
Likely Pathogenic
————4
VUS
————3
Likely Benign
————0
Benign
————0
Total—36

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

MIRLET7F1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
Open Research Assistant →
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
PubMed
Top 2 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found

Top 5 resultsSearch Europe PMC ↗

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients