MIRLET7D
Chr 9microRNA let-7d
Also known as: LET7D, MIRNLET7D, hsa-let-7d, let-7d
MIRLET7D encodes a microRNA that regulates gene expression by binding to target mRNAs and inhibiting their translation or promoting their degradation. Currently, no definitive human diseases have been established to result from mutations in this microRNA gene. The inheritance pattern and clinical significance of MIRLET7D variants remain to be determined.
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
36 submitted variants in ClinVar
Classification Summary
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 29 |
Likely Pathogenic | — | — | — | — | 4 |
VUS | — | — | — | — | 3 |
Likely Benign | — | — | — | — | 0 |
Benign | — | — | — | — | 0 |
| Total | — | 36 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
MIRLET7D · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools