MIRLET7B

Chr 22

microRNA let-7b

Also known as: LET7B, MIRNLET7B, hsa-let-7b, let-7b

NCBI Gene: 406884ENSG00000284520

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

87
ClinVar variants
81
Pathogenic / LP
—
pLI score
1
Active trials
Clinical Summary— MIRLET7B
📋
ClinVar Variants
81 Pathogenic / Likely Pathogenic· 5 VUS of 87 total submissions
💊
Clinical Trials
1 active or recruiting trial — potential therapeutic options may be available

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

87 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic78
Likely Pathogenic3
VUS5
Benign1
78
Pathogenic
3
Likely Pathogenic
5
VUS
1
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————78
Likely Pathogenic
————3
VUS
————5
Likely Benign
————0
Benign
————1
Total—87

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

MIRLET7B · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Epigenetic Modification in Preclinical and Clinical Dermatological Itch Conditions.
Fujishiro A et al.·Eur J Pain
2026Review
Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2.
Madison BB et al.·PLoS Genet
2015
Curcumin and treatment of melanoma: The potential role of microRNAs.
Lelli D et al.·Biomed Pharmacother
2017Review
TLR7 endogenous ligands remodel glycolytic macrophages and trigger skin-to-joint crosstalk in psoriatic arthritis.
Van Raemdonck K et al.·Eur J Immunol
2021Functional
Genome-wide Gene-Asbestos Exposure Interaction Association Study Identifies a Common Susceptibility Variant on 22q13.31 Associated with Lung Cancer Risk.
Liu CY et al.·Cancer Epidemiol Biomarkers Prev
2015
Replenishing co-downregulated miR-100-5p and miR-125b-5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption.
Ferraresso M et al.·Mol Oncol
2025
miR-let-7b and miR-let-7c suppress tumourigenesis of human mucosal melanoma and enhance the sensitivity to chemotherapy.
Tang H et al.·J Exp Clin Cancer Res
2019
Circulating microRNAs as biomarkers for diagnosis of early hepatocellular carcinoma associated with hepatitis B virus.
Hung CH et al.·Int J Cancer
2016
[Abnormal expression of miR-let-7b in primary biliary cirrhosis and its clinical significance].
Qian C et al.·Zhonghua Gan Zang Bing Za Zhi
2013
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov
Congenital Adrenal Hyperplasia (CAH)

Fertility And Sexual Function In CAH: CALLIOPE

RECRUITING
NCT07099456University of Roma La SapienzaStarted 2024-11-01

External Resources

Links to major genomics databases and tools