MINDY4B
Chr 3MINDY family member 4B
Also known as: C3orf76, FAM188B2
Predicted to enable K48-linked deubiquitinase activity. Predicted to be involved in protein K48-linked deubiquitination. [provided by Alliance of Genome Resources, Jul 2025]
ResearchGenerating clinical summary…
LOEUF 1.05
Clinical Summary— MINDY4B
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Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.05LOEUF
pLI 0.000
Z-score 1.38
OE 0.66 (0.43–1.05)
Highly tolerant — LoF variants common in population
Missense Constraint?
0.89Z-score
OE missense 0.81 (0.71–0.93)
141 obs / 174.0 exp
Mild missense constraint
Observed / Expected Ratios?
LoF OE?0.66 (0.43–1.05)
0≤0.351.4
Missense OE?0.81 (0.71–0.93)
0≤0.61.4
Synonymous OE?0.84
0≤1.21.6
LoF obs/exp: 13 / 19.6Missense obs/exp: 141 / 174.0Syn Z: 1.06
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
MINDY4B · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools