MILIP
Chr 17MYC inducible lncRNA inactivating p53
Also known as: MAFG-AS1, MAFG-DT
Clinical Summary— MILIP
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ClinVar Variants
7 Pathogenic / Likely Pathogenic· 1 VUS of 9 total submissions
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
9 submitted variants in ClinVar
Classification Summary
Pathogenic6
Likely Pathogenic1
VUS1
Benign1
6
Pathogenic
1
Likely Pathogenic
1
VUS
1
Benign
Curated Variants Distribution
Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable
| Classification | LoF | Missense + Inframe | Non-coding | Synonymous | Total |
|---|---|---|---|---|---|
Pathogenic | — | — | — | — | 6 |
Likely Pathogenic | — | — | — | — | 1 |
VUS | — | — | — | — | 1 |
Likely Benign | — | — | — | — | 0 |
Benign | — | — | — | — | 1 |
| Total | — | 9 | |||
Counts from ClinVar esearch · Updated hourly
View in ClinVar →Protein Context — Lollipop Plot
MILIP · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →Clinical Literature
Landmark / reviewRecent case evidence
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
Correction for Wang et al., The N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining
·Proc Natl Acad Sci U S A
2024
Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views
Jin C et al.·J Transl Med
2023
PD-1/PD-L1 Inhibitors Response in Triple-Negative Breast Cancer: Can Long Noncoding RNAs Be Associated?
Mathias C et al.·Cancers (Basel)
2023
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
A review on the roles and molecular mechanisms of MAFG-AS1 in oncogenesis.
Dabbaghi KG et al.·Pathol Res Pract
2023Review
Top 2 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer.
Zheng SM et al.·Cancer Res
2024Open Access
The N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining.
Wang PL et al.·Proc Natl Acad Sci U S A
2022Open Access
LncRNA MILIP links YBX1 to translational activation of Snai1 and promotes metastasis in clear cell renal cell carcinoma.
Wang Y et al.·J Exp Clin Cancer Res
2022Open Access
The pan-cancer lncRNA MILIP links c-Myc to p53 repression.
Feng YC et al.·Mol Cell Oncol
2020Open Access
c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis.
Feng YC et al.·Nat Commun
2020Open Access
Top 5 resultsSearch Europe PMC ↗
External Resources
Links to major genomics databases and tools