MGST2

Chr 4

microsomal glutathione S-transferase 2

Also known as: GST2, MGST-II

NCBI Gene: 4258ENSG00000085871UniProt: Q99735OMIM: 601733

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]

OMIMResearchGenerating clinical summary…
1
Active trials
8
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.93
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.93LOEUF
pLI 0.078
Z-score 1.71
OE 0.36 (0.16–0.93)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
0.37Z-score
OE missense 0.88 (0.73–1.07)
72 obs / 81.5 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.36 (0.16–0.93)
0≤0.351.4
Missense OE?0.88 (0.73–1.07)
0≤0.61.4
Synonymous OE?1.27
0≤1.21.6
LoF obs/exp: 3 / 8.3Missense obs/exp: 72 / 81.5Syn Z: -1.19

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

MGST2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients