METTL14

Chr 4

methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit

Also known as: hMETTL14

NCBI Gene: 57721 ENSG00000145388 UniProt: Q9HCE5 OMIM: 616504

METTL14 forms a heterodimer with METTL3 that functions as an N6-methyltransferase complex, methylating adenosine residues in mRNAs to regulate mRNA stability, circadian clock function, and cortical neurogenesis. Biallelic mutations cause developmental delay, intellectual disability, and microcephaly with autosomal recessive inheritance. The gene is highly constrained against loss-of-function variants (LOEUF 0.607), reflecting its essential role in neurodevelopment and cellular differentiation.

OMIM ResearchSummary from RefSeq, UniProt

Enables mRNA binding activity and mRNA m(6)A methyltransferase activity. Involved in mRNA modification; mRNA splicing, via spliceosome; and mRNA stabilization. Located in nucleoplasm. Part of RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Jun 2026]

OMIM ResearchGenerating clinical summary…

Active trials

412

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

0.61

LOEUF

Mechanism· predicted