MEIOB

Chr 16AR

meiosis specific with OB-fold

Also known as: C16orf73, POF23, SPGF22, gs129

NCBI Gene: 254528 ENSG00000162039 UniProt: Q8N635 OMIM: 617670

MEIOB encodes a single-stranded DNA-binding protein required for homologous recombination during meiosis I, facilitating double-strand break repair and crossover formation. Biallelic mutations cause autosomal recessive premature ovarian failure and male spermatogenic failure, affecting reproductive function. The gene shows strong constraint against loss-of-function variants (pLI near 0, LOEUF 1.4), reflecting its essential role in meiotic processes.

OMIM ResearchSummary from RefSeq, OMIM, UniProt

Predicted to enable chromatin binding activity; single-stranded DNA 3'-5' DNA exonuclease activity; and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; fertilization; and meiotic nuclear division. Located in nucleus. Implicated in primary ovarian insufficiency and spermatogenic failure 22. [provided by Alliance of Genome Resources, Jul 2025]

OMIM ResearchGenerating clinical summary…

ARLOEUF 1.422 OMIM phenotypes

Clinical Summary— MEIOB

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Population Constraint (gnomAD)

Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.

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