MED25
Chr 19mediator complex subunit 25
Also known as: ACID1, ARC92, BVSYS, CMT2B2, P78, PTOV2, TCBAP0758
This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]
Clinical highlights
Some data sources returned errors (1)
omim: Error: OMIM fetch failed: 429
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
MED25 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
Toxoplasma Gondii Seroprevalence Among Children With Some Neuropsychiatric Disorders
NOT YET RECRUITINGEffect of Ceftazidime-Avibactam on Carbapenemase-Producing Klebsiella Pneumoniae
NOT YET RECRUITINGPhenotypic and Genotypic Detection of Biofilm Formation and Efflux Pump Activity in Multi-drug Resistant Klebsiella Pneumoniae
NOT YET RECRUITINGThe Value of Interleukin-1β and Interleukin-33 Genetic Expression in the Pathogenesis and Differentiation of Primary ITP and SLE-Related Thrombocytopenia
NOT YET RECRUITINGAssociation Between Matrix Metalloproteinase-9 Gene Polymorphism and Susceptibility to Primary Open Angle Glaucoma Patients in Sohag University Hospital
NOT YET RECRUITING"Cytotoxic T Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Single-nucleotide Polymorphism in Primary Immune Thrombocytopenic Purpura in Children"
NOT YET RECRUITINGImpact of Siderophore Genes on Cefiderocol Susceptibility in Carbapenem Resistant Hypervirulent Klebsiella Pneumoniae
NOT YET RECRUITINGHealth-related Quality of Life, Electrocardiographic and Holter Findings in Children With Familial Mediterranean Fever
ACTIVE NOT RECRUITINGExternal Resources
Links to major genomics databases and tools