MED16

Chr 19

mediator complex subunit 16

Also known as: DRIP92, GGNS, THRAP5, TRAP95

NCBI Gene: 10025ENSG00000175221UniProt: Q9Y2X0

Enables nuclear thyroid hormone receptor binding activity and transcription coactivator activity. Involved in positive regulation of transcription initiation by RNA polymerase II. Located in nucleus. Part of core mediator complex and mediator complex. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
LOEUF 1.03
Clinical Summary— MED16
⚡
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
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Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.03LOEUF
pLI 0.000
Z-score 1.41
OE 0.74 (0.54–1.03)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-1.67Z-score
OE missense 1.19 (1.12–1.27)
703 obs / 588.7 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.74 (0.54–1.03)
0≤0.351.4
Missense OE?1.19 (1.12–1.27)
0≤0.61.4
Synonymous OE?1.72
0≤1.21.6
LoF obs/exp: 26 / 35.0Missense obs/exp: 703 / 588.7Syn Z: -9.45

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

MED16 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

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External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients