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MDCMC

Chr 22AR

choline kinase beta

Also known as: CHETK, CHKL, CK, CKB, CKEKB, EK, EKB, MDCMC

The protein encoded by this gene functions as both a choline kinase and ethanolamine kinase, catalyzing the first step in phosphatidylcholine and phosphatidylethanolamine biosynthesis in all animal cells. Mutations cause autosomal recessive megaloblastic anemia with developmental delay and neurological abnormalities. This gene has a GeneReviews entry indicating established clinical significance.

GeneReviewsOMIMResearchSummary from RefSeq
AR1 OMIM phenotype
📖
GeneReview available — MDCMC
Authoritative clinical overview · Recommended first read
Open GeneReview ↗
Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/MDCMC?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

MDCMC · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →
Clinical Literature
Open Research Assistant →
Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
Top 5 full-text resultsSearch PubTator3 ↗
Key Publications
Landmark & review papers · by relevance
PubMed
Top 2 results · since 2015Search PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC

No open access results found