MCHR2

Chr 6

melanin concentrating hormone receptor 2

Also known as: GPR145, GPRv17, MCH-2R, MCH-R2, MCH2, MCH2R, MCHR-2, SLT

NCBI Gene: 84539 ENSG00000152034 UniProt: Q969V1 OMIM: 606111

Predicted to enable galanin receptor activity. Predicted to be involved in neuropeptide signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

OMIM Research

Predicted to enable galanin receptor activity. Predicted to be involved in neuropeptide signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.20

LOEUF

Multiple*

Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD

Tolerant — LoF & missense variants common in population

LoF Constraint?

1.20LOEUF

pLI 0.000

Z-score 1.02

OE 0.71 (0.43–1.20)

Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?

0.51Z-score

OE missense 0.89 (0.78–1.02)

161 obs / 180.3 exp

Tolerant

Mild missense constraint

Observed / Expected Ratios?

LoF OE?0.71 (0.43–1.20)

0≤0.351.4

Missense OE?0.89 (0.78–1.02)

0≤0.61.4

Synonymous OE?1.05

0≤1.21.6

LoF obs/exp: 10 / 14.2Missense obs/exp: 161 / 180.3Syn Z: -0.32

Background carrier burden — how many people carry a rare variant somewhere in MCHR2?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 140

416 rare PASS variants

Rare truncating (LoF)

1 in 940

66 rare PASS variants

Rare synonymous (reference)

1 in 370

161 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for MCHR2. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 170	1 in 1,000
South Asian	~43k	1 in 260	1 in 690
Remaining (unassigned)	~30k	1 in 160	1 in 900
European (Finnish)	~27k	1 in 420	1 in 1,100
Admixed American	~22k	1 in 250	1 in 360
African / African American	~21k	1 in 240	1 in 520
East Asian	~20k	1 in 210	1 in 1,000
Ashkenazi Jewish	~13k	1 in 1,100	1 in 970
Middle Eastern	~2,884	1 in 130	≈ 1 in 710

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): All 5 coding exons well covered in gnomAD exomes and genomes.? see exons ↓