MARCHF6-DT

Chr 5

MARCHF6 divergent transcript

Also known as: PACMP

NCBI Gene: 101929977ENSG00000259802UniProt: P0DW81

Enables poly-ADP-D-ribose binding activity. Involved in negative regulation of protein ubiquitination and positive regulation of DNA repair. Is active in nucleolus and site of DNA damage. [provided by Alliance of Genome Resources, Jul 2025]

44
ClinVar variants
41
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— MARCHF6-DT
📋
ClinVar Variants
41 Pathogenic / Likely Pathogenic· 3 VUS of 44 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

44 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic41
VUS3
41
Pathogenic
3
VUS

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————41
Likely Pathogenic
————0
VUS
————3
Likely Benign
————0
Benign
————0
Total—44

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

MARCHF6-DT · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype

OMIM

No OMIM entries found.

Clinical Literature
Landmark / reviewRecent case evidence

No publications found for MARCHF6-DT

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools