MAPK15

Chr 8

mitogen-activated protein kinase 15

Also known as: ERK7, ERK8

NCBI Gene: 225689 ENSG00000181085 UniProt: Q8TD08

MAPK15 encodes an atypical MAP kinase that regulates autophagy, primary ciliogenesis, protein trafficking, and genome integrity through its kinase activity. Mutations cause autosomal recessive neurodevelopmental disorders with intellectual disability, seizures, and movement abnormalities. The gene shows very low constraint against loss-of-function variants (LOEUF 1.506), consistent with recessive inheritance patterns.

ResearchSummary from RefSeq, UniProt

Enables MAP kinase activity and chromatin binding activity. Involved in several processes, including dopamine uptake; protein localization to ciliary transition zone; and regulation of COPII vesicle coating. Located in several cellular components, including Golgi apparatus; autophagosome; and microtubule organizing center. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.51

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)