MAPK11
Chr 22mitogen-activated protein kinase 11
Also known as: P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta
The protein is a serine/threonine kinase that functions as an essential component of the p38 MAP kinase signaling pathway, regulating cellular responses to inflammatory cytokines and environmental stress through phosphorylation of transcription factors and other downstream targets. MAPK11 is highly tolerant to loss-of-function variation (LOEUF 0.79), and no Mendelian diseases have been definitively associated with mutations in this gene to date. The gene's tolerance to variation suggests that if pathogenic variants are identified in the future, they would likely be very rare.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Moderately missense-constrained (top ~2.5%)
This gene has evidence for multiple mechanisms of pathogenicity (dominant-negative and gain-of-function). Both the Badonyi & Marsh prediction and the broader genomic evidence point to dominant-negative as the predominant mechanism. Different variants in this gene may act through different mechanisms — interpret in context of the specific variant.
Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
MAPK11 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools