MAP3K21

Chr 1

mitogen-activated protein kinase kinase kinase 21

Also known as: MLK4, dJ862P8.3

NCBI Gene: 84451ENSG00000143674UniProt: Q5TCX8

Predicted to enable JUN kinase kinase kinase activity and protein homodimerization activity. Predicted to be involved in protein autophosphorylation and signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.69
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.69LOEUF
pLI 0.000
Z-score 3.01
OE 0.45 (0.31–0.69)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
1.78Z-score
OE missense 0.78 (0.72–0.85)
411 obs / 525.6 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.45 (0.31–0.69)
0≤0.351.4
Missense OE?0.78 (0.72–0.85)
0≤0.61.4
Synonymous OE?0.94
0≤1.21.6
LoF obs/exp: 16 / 35.3Missense obs/exp: 411 / 525.6Syn Z: 0.68

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

MAP3K21 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients