MAP1LC3C

Chr 1

microtubule associated protein 1 light chain 3 gamma

Also known as: ATG8J, LC3C

NCBI Gene: 440738ENSG00000197769UniProt: Q9BXW4

Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010]

ResearchGenerating clinical summary…
0
Active trials
8
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.91
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.91LOEUF
pLI 0.000
Z-score -0.70
OE 1.33 (0.72–1.91)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.50Z-score
OE missense 0.85 (0.70–1.03)
73 obs / 85.9 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?1.33 (0.72–1.91)
0≤0.351.4
Missense OE?0.85 (0.70–1.03)
0≤0.61.4
Synonymous OE?1.16
0≤1.21.6
LoF obs/exp: 7 / 5.3Missense obs/exp: 73 / 85.9Syn Z: -0.72

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

MAP1LC3C · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients