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MAHCX

Chr XXLR

host cell factor C1

Also known as: CFF, HCF, HCF-1, HCF1, HFC1, MAHCX, MRX3, PPP1R89

The protein functions as a nuclear coactivator involved in cell cycle control and transcriptional regulation, containing Kelch repeats and HCF repeats that undergo proteolytic cleavage to form functional N- and C-terminal chains. Mutations cause methylmalonic aciduria and homocysteinemia, cblX type, which involves defects in vitamin B12 metabolism affecting multiple organ systems. This condition follows X-linked recessive inheritance.

OMIMResearchSummary from RefSeq, OMIM
XLR1 OMIM phenotype
Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/MAHCX?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

MAHCX · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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No publications found for MAHCX