MAGED4
Chr XMAGE family member D4
Also known as: MAGE-D4, MAGE-E1, MAGE1
The protein may enhance ubiquitin ligase activity of RING-type E3 ubiquitin ligases and is predicted to negatively regulate transcription by RNA polymerase II in the nucleus. Currently, no established human diseases have been definitively linked to mutations in this gene. The gene shows relatively low constraint to loss-of-function variation, suggesting it may tolerate some degree of functional disruption.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
MAGED4 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools