LY9

Chr 1

lymphocyte antigen 9

Also known as: CD229, SLAMF3, hly9, mLY9

NCBI Gene: 4063ENSG00000122224UniProt: Q9HBG7OMIM: 600684

LY9 belongs to the SLAM family of immunomodulatory receptors (see SLAMF1; MIM 603492) and interacts with the adaptor molecule SAP (SH2D1A; MIM 300490) (Graham et al., 2006 [PubMed 16365421]).[supplied by OMIM, Mar 2008]

OMIMResearchGenerating clinical summary…
0
Active trials
21
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.11
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.11LOEUF
pLI 0.000
Z-score 1.08
OE 0.78 (0.56–1.11)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.22Z-score
OE missense 1.03 (0.95–1.13)
368 obs / 356.5 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.78 (0.56–1.11)
0≤0.351.4
Missense OE?1.03 (0.95–1.13)
0≤0.61.4
Synonymous OE?0.92
0≤1.21.6
LoF obs/exp: 23 / 29.3Missense obs/exp: 368 / 356.5Syn Z: 0.80

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

LY9 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients