LY86

Chr 6

lymphocyte antigen 86

Also known as: MD-1, MD1, MMD-1, dJ80N2.1

NCBI Gene: 9450ENSG00000112799UniProt: O95711

Acts upstream of or within positive regulation of lipopolysaccharide-mediated signaling pathway. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
16
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.75
LOEUF
—
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.75LOEUF
pLI 0.000
Z-score -0.01
OE 1.00 (0.57–1.75)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.34Z-score
OE missense 1.10 (0.93–1.31)
94 obs / 85.1 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.00 (0.57–1.75)
0≤0.351.4
Missense OE?1.10 (0.93–1.31)
0≤0.61.4
Synonymous OE?1.10
0≤1.21.6
LoF obs/exp: 7 / 7.0Missense obs/exp: 94 / 85.1Syn Z: -0.47

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

LY86 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients