LY6G6F-LY6G6D

Chr 6

LY6G6F-LY6G6D readthrough

Also known as: G6F-LY6G6D, MEGT-1, MEGT1

NCBI Gene: 110599563ENSG00000250641

This locus represents naturally occurring readthrough transcription between the neighboring LY6G6F (lymphocyte antigen 6 family member G6F) and LY6G6D (lymphocyte antigen 6 family member G6D) genes on chromosome 6. The readthrough transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jul 2017]

ResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.16
LOEUF
—
Mechanism
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.16LOEUF
pLI 0.000
Z-score 1.05
OE 0.73 (0.48–1.16)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.65Z-score
OE missense 0.88 (0.78–0.99)
197 obs / 224.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.73 (0.48–1.16)
0≤0.351.4
Missense OE?0.88 (0.78–0.99)
0≤0.61.4
Synonymous OE?0.83
0≤1.21.6
LoF obs/exp: 13 / 17.8Missense obs/exp: 197 / 224.4Syn Z: 1.32

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

LY6G6F-LY6G6D · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients