LY6D

Chr 8

lymphocyte antigen 6 family member D

Also known as: E48, Ly-6D

NCBI Gene: 8581 ENSG00000167656 UniProt: Q14210 OMIM: 606204

The LY6D protein acts as a specification marker during the earliest stages of lymphocyte development, particularly marking early B-cell specification and distinguishing between B- and T-cell developmental pathways. Currently, no established human diseases have been linked to LY6D mutations in the medical literature. The gene shows low constraint against loss-of-function variants (pLI 0.03, LOEUF 1.87), suggesting it may tolerate functional disruption relatively well.

OMIM ResearchSummary from RefSeq, UniProt

Predicted to be involved in lymphocyte differentiation. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Jul 2025]

OMIM ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

1.87

LOEUF

Mechanism· predicted