LURAP1L

Chr 9

leucine rich adaptor protein 1 like

Also known as: C9orf150, HYST0841, LRAP35b, bA3L8.2

NCBI Gene: 286343ENSG00000153714UniProt: Q8IV03OMIM: 616130

Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
2
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.38
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.38LOEUF
pLI 0.025
Z-score 1.00
OE 0.54 (0.25–1.38)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-1.13Z-score
OE missense 1.28 (1.13–1.46)
163 obs / 127.2 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.54 (0.25–1.38)
0≤0.351.4
Missense OE?1.28 (1.13–1.46)
0≤0.61.4
Synonymous OE?1.27
0≤1.21.6
LoF obs/exp: 3 / 5.5Missense obs/exp: 163 / 127.2Syn Z: -1.53

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

LURAP1L · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients