LUCAT1

Chr 5

lung cancer associated transcript 1

Also known as: SCAL1, SCAT5

NCBI Gene: 100505994ENSG00000248323
30
ClinVar variants
27
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— LUCAT1
📋
ClinVar Variants
27 Pathogenic / Likely Pathogenic· 3 VUS of 30 total submissions

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

30 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic22
Likely Pathogenic5
VUS3
22
Pathogenic
5
Likely Pathogenic
3
VUS

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories· variant type breakdown unavailable

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
————22
Likely Pathogenic
————5
VUS
————3
Likely Benign
————0
Benign
————0
Total—30

Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

LUCAT1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Exosome-transmitted LUCAT1 promotes stemness transformation and chemoresistance in bladder cancer by binding to IGF2BP2.
Zhan Y et al.·J Exp Clin Cancer Res
2025
High expression of long noncoding RNA LUCAT1 correlates with a poor clinical outcome in solid tumors: A systematic review and meta-analysis.
Lv P et al.·Pathol Res Pract
2020Meta-analysis
Lung cancer associated transcript 1 binds heat shock protein 90 to promote growth of hepatocellular carcinoma.
Bai Y et al.·Cell Signal
2025
LUCAT1-Mediated Competing Endogenous RNA (ceRNA) Network in Triple-Negative Breast Cancer.
Verma D et al.·Cells
2024
Clinical Value of lncRNA LUCAT1 Expression in Liver Cancer and its Potential Pathways.
Jiao Y et al.·J Gastrointestin Liver Dis
2019
Low LncRNA LUCAT1 Expression Assists in the Diagnosis of Chronic Heart Failure and Predicts Poor Prognosis.
Wang J et al.·Int Heart J
2023
Long non-coding RNA LUCAT1 modulates methotrexate resistance in osteosarcoma via miR-200c/ABCB1 axis.
Han Z et al.·Biochem Biophys Res Commun
2018
Disulfidptosis-related gene signatures as prognostic biomarkers and predictors of immunotherapy response in HNSCC.
Qin H et al.·Front Immunol
2025
Long non-coding RNA LUCAT1/miR-5582-3p/TCF7L2 axis regulates breast cancer stemness via Wnt/β-catenin pathway.
Zheng A et al.·J Exp Clin Cancer Res
2019
Long Noncoding RNAs CARMN, LUCAT1, SMILR, and MALAT1 in Thoracic Aortic Aneurysm: Validation of Biomarkers in Clinical Samples.
Patamsytė V et al.·Dis Markers
2020
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools