LRRN4CL

Chr 11

LRRN4 C-terminal like

NCBI Gene: 221091 ENSG00000177363 UniProt: Q8ND94

The protein encoded by this gene is predicted to be a membrane-localized protein, though its specific function remains unclear. Mutations in LRRN4CL have not been definitively associated with human disease, and no clear inheritance pattern has been established. The gene shows no evidence of constraint against loss-of-function variants, suggesting it may be tolerant to functional disruption.

ResearchSummary from RefSeq

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.93

LOEUF

—

Mechanism

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD

Tolerant — LoF & missense variants common in population

LoF Constraint?

1.93LOEUF

pLI 0.000

Z-score -0.92

OE 1.50 (0.75–1.93)

Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?

0.11Z-score

OE missense 0.98 (0.85–1.12)

143 obs / 146.7 exp

Tolerant

Mild missense constraint

Observed / Expected Ratios?

LoF OE?1.50 (0.75–1.93)

0≤0.351.4

Missense OE?0.98 (0.85–1.12)

0≤0.61.4

Synonymous OE?0.84

0≤1.21.6

LoF obs/exp: 6 / 4.0Missense obs/exp: 143 / 146.7Syn Z: 1.06

Background carrier burden — how many people carry a rare variant somewhere in LRRN4CL?

gnomAD v4 · ~730k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 290

377 rare PASS variants

Rare truncating (LoF)

1 in 1,200

62 rare PASS variants

Rare synonymous (reference)

1 in 180

169 rare PASS variants

Rare missense and truncating variants are carried at similar rates in LRRN4CL; this gene does not show strong loss-of-function constraint by this measure. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 370	1 in 3,300
South Asian	~43k	1 in 160	1 in 870
Remaining (unassigned)	~30k	1 in 240	1 in 790
European (Finnish)	~26k	1 in 1,500	≈ 1 in 8,600
Admixed American	~22k	1 in 140	1 in 1,200
African / African American	~21k	1 in 170	1 in 580
East Asian	~20k	1 in 210	≈ 1 in 6,000
Ashkenazi Jewish	~13k	≈ 1 in 3,300	≈ 1 in 13,000
Middle Eastern	~2,884	1 in 210	≈ 1 in 960

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): All 1 coding exons well covered in gnomAD exomes and genomes.? see exons ↓