LRRN1

Chr 3

leucine rich repeat neuronal 1

Also known as: FIGLER3, NLRR-1, NLRR1

NCBI Gene: 57633 ENSG00000175928 UniProt: O75427

The LRRN1 protein regulates signaling by multiple toll-like receptors and acts as a broad-spanning regulator of the innate immune response, while also being predicted to regulate synapse assembly. This gene is highly constrained against loss-of-function mutations (pLI 0.97, LOEUF 0.32), but specific disease associations and inheritance patterns have not been established in the provided data. Additional clinical and genetic studies are needed to define the phenotypic spectrum associated with LRRN1 variants.

ResearchSummary from RefSeq, UniProt

Predicted to enable signaling receptor activity. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be active in plasma membrane. Biomarker of stomach cancer. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.32

LOEUF· LoF intol.

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Mechanism

Some data sources returned errors (1)

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