LRRN1

Chr 3

leucine rich repeat neuronal 1

Also known as: FIGLER3, NLRR-1, NLRR1

NCBI Gene: 57633ENSG00000175928UniProt: O75427

Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Biomarker of stomach cancer. [provided by Alliance of Genome Resources, Jul 2025]

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0
Active trials
8
Pubs (1 yr)
0
P/LP submissions
—
P/LP missense
0.32
LOEUF· LoF intol.
—
Mechanism
Clinical Summary— LRRN1
⚡
Population Constraint (gnomAD)
Highly constrained gene — heterozygous loss-of-function variants are very rare in the population (pLI 0.97). One damaged copy is likely sufficient to cause disease.
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Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
LoF intolerant — likely haploinsufficient
LoF Constraint
0.32LOEUF
pLI 0.970
Z-score 3.69
OE 0.10 (0.04–0.32)
Highly constrained

Highly LoF-intolerant (top ~10% of genes)

Missense Constraint
0.35Z-score
OE missense 0.95 (0.87–1.04)
368 obs / 387.3 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE0.10 (0.04–0.32)
0≤0.351.4
Missense OE0.95 (0.87–1.04)
0≤0.61.4
Synonymous OE1.18
0≤1.21.6
LoF obs/exp: 2 / 19.7Missense obs/exp: 368 / 387.3Syn Z: -1.78

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

LRRN1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Full-Text Mentions
NLP-detected gene mentions in article bodies · via PubTator3
PubTator3
Top 5 full-text resultsSearch PubTator3 ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Whole-genome sequencing identifies variants in ANK1, LRRN1, HAS1, and other genes and regulatory regions for stroke in type 1 diabetes.
Antikainen AA et al.·Sci Rep
2024
Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti.
Maunsell HR et al.·J Neurosci
2023Functional
Knockdown of LRRN1 inhibits malignant phenotypes through the regulation of HIF-1α/Notch pathway in pancreatic ductal adenocarcinoma.
Zhang Y et al.·Mol Ther Oncolytics
2021Open Access
Lrrn1 is required for formation of the midbrain-hindbrain boundary and organiser through regulation of affinity differences between midbrain and hindbrain cells in chick.
Tossell K et al.·Dev Biol
2011Open Access
Analysis of Lrrn1 expression and its relationship to neuromeric boundaries during chick neural development.
Andreae LC et al.·Neural Dev
2007Open Access
Top 5 resultsSearch Europe PMC ↗

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients