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LRRC58-DT

Chr 3

butyrophilin like 12, pseudogene

Also known as: LRRC58-DT

NCBI Gene: 100130701

I cannot provide a clinical summary for LRRC58-DT as no information about protein function, associated diseases, or inheritance patterns was provided in the data below your request. To write an accurate clinical summary following your guidelines, I would need details about what the protein does, what conditions result from mutations, and the inheritance pattern.

Research

ResearchGenerating clinical summary…

Clinical Summary— LRRC58-DT

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ClinVar Variants

49 VUS of 63 total submissions

Explore recent and relevant literature in Research Assistant →

Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for /lookup/symbol/homo_sapiens/LRRC58-DT?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

63 submitted variants in ClinVar

ClinVar

Classification Summary

VUS49

Likely Benign1

VUS

Likely Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

Classification	Missense + Inframe	Synonymous	Total
Pathogenic	0	0	0
Likely Pathogenic	0	0	0
VUS	49	0	49
Likely Benign	0	1	1
Benign	0	0	0
Total	49	1	50

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

10 pathogenic / likely-pathogenic (of 13) ClinVar copy-number / structural variants overlap LRRC58-DT — these span large chromosomal regions, not the gene specifically, and are excluded from the counts above. Explore in CNV tools →