LRRC42

Chr 1

leucine rich repeat containing 42

Also known as: dJ167A19.4

This protein is a leucine-rich repeat containing protein with unknown specific function. Mutations cause autosomal recessive primary ciliary dyskinesia, a disorder affecting ciliary motility that presents with chronic respiratory tract infections, bronchiectasis, and often situs inversus. The gene shows low constraint against loss-of-function variants, consistent with its recessive inheritance pattern.

LOEUF 1.12
Clinical SummaryLRRC42
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint
1.12LOEUF
pLI 0.000
Z-score 1.15
OE 0.73 (0.481.12)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
-0.22Z-score
OE missense 1.04 (0.941.16)
244 obs / 234.5 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios
LoF OE0.73 (0.481.12)
00.351.4
Missense OE1.04 (0.941.16)
00.61.4
Synonymous OE0.91
01.21.6
LoF obs/exp: 15 / 20.6Missense obs/exp: 244 / 234.5Syn Z: 0.70

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

LRRC42 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC