LRRC37A2

Chr 17

leucine rich repeat containing 37 member A2

Also known as: LRRC37

NCBI Gene: 474170 ENSG00000238083 UniProt: A6NM11

The protein is predicted to have ATP binding and hydrolysis activity and to be involved in SNARE complex disassembly and protein transport in the cytoplasm and membranes. This gene shows extremely low constraint against loss-of-function variants (pLI near 0, LOEUF ~1), suggesting it may tolerate such variants without causing disease. No established disease associations have been reported for mutations in this gene.

ResearchSummary from RefSeq

Predicted to enable ATP binding activity; ATP hydrolysis activity; and metal ion binding activity. Predicted to be involved in SNARE complex disassembly and protein transport. Predicted to be located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.04

LOEUF

Mechanism· predicted

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429