LRRC3

Chr 21

leucine rich repeat containing 3

Also known as: C21orf102, C21orf30, LRRC3DN

NCBI Gene: 81543ENSG00000160233UniProt: Q9BY71OMIM: 617620

Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.72
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.72LOEUF
pLI 0.003
Z-score 0.35
OE 0.83 (0.40–1.72)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.26Z-score
OE missense 0.95 (0.83–1.07)
169 obs / 178.7 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.83 (0.40–1.72)
0≤0.351.4
Missense OE?0.95 (0.83–1.07)
0≤0.61.4
Synonymous OE?1.06
0≤1.21.6
LoF obs/exp: 4 / 4.8Missense obs/exp: 169 / 178.7Syn Z: -0.44

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

LRRC3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients