LRRC24

Chr 8

leucine rich repeat containing 24

Also known as: LRRC14OS

NCBI Gene: 441381ENSG00000254402UniProt: Q50LG9OMIM: 620672

Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane; extracellular matrix; and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

OMIMResearchGenerating clinical summary…
0
Active trials
0
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.96
LOEUF
Multiple*
Mechanism· predicted

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
0.96LOEUF
pLI 0.001
Z-score 1.67
OE 0.51 (0.29–0.96)
Tolerant

Typical tolerance to LoF variation

Missense Constraint?
-0.68Z-score
OE missense 1.12 (1.01–1.23)
295 obs / 264.0 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.51 (0.29–0.96)
0≤0.351.4
Missense OE?1.12 (1.01–1.23)
0≤0.61.4
Synonymous OE?1.39
0≤1.21.6
LoF obs/exp: 7 / 13.7Missense obs/exp: 295 / 264.0Syn Z: -3.51

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

LRRC24 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients