LRRC15

Chr 3

leucine rich repeat containing 15

Also known as: LIB

NCBI Gene: 131578 ENSG00000172061 UniProt: Q8TF66

Enables several functions, including fibronectin binding activity; laminin binding activity; and protein sequestering activity. Involved in several processes, including host-mediated suppression of symbiont invasion; negative regulation of protein localization to plasma membrane; and receptor-mediated virion attachment to host cell. Located in plasma membrane. Is active in apical plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

Research

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.41

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD

Tolerant — LoF & missense variants common in population

LoF Constraint?

1.41LOEUF

pLI 0.000

Z-score 0.34

OE 0.91 (0.60–1.41)

Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?

-0.46Z-score

OE missense 1.07 (0.98–1.17)

375 obs / 350.7 exp

Tolerant

Tolerant to missense variation

Observed / Expected Ratios?

LoF OE?0.91 (0.60–1.41)

0≤0.351.4

Missense OE?1.07 (0.98–1.17)

0≤0.61.4

Synonymous OE?1.15

0≤1.21.6

LoF obs/exp: 14 / 15.5Missense obs/exp: 375 / 350.7Syn Z: -1.51

Background carrier burden — how many people carry a rare variant somewhere in LRRC15?

gnomAD v4 · ~731k individuals · PASS only

Rare means allele frequency under

Rare missense

1 in 70

822 rare PASS variants

Rare truncating (LoF)

1 in 1,400

104 rare PASS variants

Rare synonymous (reference)

1 in 69

358 rare PASS variants

Truncating variants are far rarer here than missense — that gap, in human units, is what constraint means for LRRC15. A background rate for each class, not the frequency of any particular variant; thin-coverage exons undercount.

By genetic ancestry · 9 gnomAD groups · rare = under 0.1% in that group

Group	People	Missense	Truncating
European (non-Finnish)	~556k	1 in 110	1 in 1,500
South Asian	~43k	1 in 47	1 in 1,500
Remaining (unassigned)	~30k	1 in 45	1 in 1,200
European (Finnish)	~27k	1 in 300	≈ 1 in 5,800
Admixed American	~22k	1 in 66	1 in 930
African / African American	~21k	1 in 55	1 in 1,200
East Asian	~20k	1 in 65	1 in 500
Ashkenazi Jewish	~13k	1 in 180	≈ 1 in 3,300
Middle Eastern	~2,884	1 in 54	none seen

Each group is summed over the variants that are rare in that group. Grey ≈ figures rest on fewer than five expected carriers — too few to distinguish groups. Differences mostly reflect how many people were sampled and how much variation each ancestry carries, not disease risk.

Exome coverage (gnomAD): All 1 coding exons well covered in gnomAD exomes and genomes.? see exons ↓