LPAR6
Chr 13ARlysophosphatidic acid receptor 6
Also known as: ARWH1, HYPT8, LAH3, LPA-6, P2RY5, P2Y5
The LPAR6 protein is a G-protein coupled receptor that binds lysophosphatidic acid and is important for maintaining hair growth and texture through cAMP signaling pathways. Mutations cause autosomal recessive hypotrichosis and woolly hair disorders characterized by sparse, abnormally textured hair that is typically apparent from birth or early childhood. These conditions primarily affect hair follicle development and maintenance without significant involvement of other organ systems.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Mild missense constraint
Predictions shown for reference only — model trained on dominant genes, not applicable to AR conditions.
The Badonyi & Marsh prediction model was trained exclusively on dominant disease genes. Predictions are not reliable for genes with autosomal recessive inheritance and are shown at reduced opacity for reference only.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
LPAR6 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools