LPAR5

Chr 12

lysophosphatidic acid receptor 5

Also known as: GPR92, GPR93, KPG_010, LPA5

NCBI Gene: 57121 ENSG00000184574 UniProt: Q9H1C0

The protein functions as a G protein-coupled receptor that transmits signals from lysophosphatidic acid to mediate diverse cellular processes. Mutations cause autosomal recessive hypotrichosis simplex, characterized by sparse hair growth typically present from birth. The gene shows minimal constraint against loss-of-function variants, consistent with recessive inheritance requiring biallelic mutations to cause disease.

ResearchSummary from RefSeq, UniProt

This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

—

P/LP missense

1.07

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)