LNX2

Chr 13

ligand of numb-protein X 2

Also known as: PDZRN1

NCBI Gene: 222484 ENSG00000139517 UniProt: Q8N448

LNX2 encodes a protein with ubiquitin-protein transferase activity that regulates neural precursor cell proliferation and neuron differentiation at the plasma membrane. The gene is highly constrained against loss-of-function variants (pLI nearly 1.0), but specific disease associations have not been established in the provided data. Loss-of-function mutations would be expected to cause neurodevelopmental disorders given the protein's role in neural development and the gene's intolerance to such variants.

ResearchSummary from RefSeq

Enables identical protein binding activity. Predicted to be involved in nervous system development. Predicted to act upstream of or within neural precursor cell proliferation and neuron differentiation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

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LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (2)