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LIS4
Chr 16ARnudE neurodevelopment protein 1
Also known as: HOM-TES-87, LIS4, MHAC, NDE, NUDE, NUDE1
This gene encodes a centrosomal protein that regulates dynein function and is essential for microtubule organization, mitosis, and neuronal migration. Mutations cause lissencephaly 4, characterized by lissencephaly, severe brain atrophy, microcephaly, and severe cognitive disability. The condition follows autosomal recessive inheritance.
Some data sources returned errors (2)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/LIS4?content-type=application/json&expand=1
gnomad: Error: Gene not found
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
LIS4 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools