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LIS2
Chr 7ARreelin
Also known as: ETL7, LIS2, PRO1598, RL
This gene encodes a large secreted extracellular matrix protein that controls cell-cell interactions critical for neuronal positioning and migration during brain development. Mutations cause autosomal recessive lissencephaly 2 (Norman-Roberts type), characterized by lissencephaly with cerebellar hypoplasia. The condition follows autosomal recessive inheritance and represents a severe developmental brain malformation affecting cortical and cerebellar development.
Some data sources returned errors (2)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/LIS2?content-type=application/json&expand=1
gnomad: Error: Gene not found
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
LIS2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools