LINGO2
Chr 9leucine rich repeat and Ig domain containing 2
Also known as: LERN3, LRRN6C
LINGO2 encodes a membrane protein that positively regulates synapse assembly and is active at glutamatergic synapses and synaptic membranes. The gene is highly constrained against loss-of-function variants (pLI=0.86, LOEUF=0.42), suggesting that mutations likely cause significant developmental or neurological phenotypes. However, specific disease associations and inheritance patterns for LINGO2 have not been established in the current literature.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
LINGO2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools